Frequency and linkage disequilibrium,
, with varying policies and epistasis modes for a drug usage of 30% and fitness penalty of 10%. Each column depicts a different policy (MFT or sequential application) and epistasis mode (full epistasis or DGF). The top row shows the frequency over time of all genotypes: green is the fully sensitive genotype, red is the fully resistant genotype, and yellow lines represent genotypes containing one, two or three resistance mutations. The bottom row plots LD between two loci encoding for the same drug (green) and two loci encoding resistance to different drugs (black). Note that the Y scale for LD (r) is different on each column.