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Table 4 Treatment outcome stratified by country

From: Multicentre study evaluating the non-inferiority of the new paediatric formulation of artesunate/amodiaquine versus artemether/lumefantrine for the management of uncomplicated Plasmodium falciparum malaria in children in Cameroon, Ivory Coast and Senegal

Treatment outcome stratified by country Artesunate/Amodiaquine Artemether/Lumefantrine p value
Senegal (160 patients) 80 80  
ITT analysis    
Early treatment failure 00 00 --
Crude Parasitological failure at day 28 01/88 (1.1%) 01/72 (1.4%) 1
PCR adjusted failure rate at day 28 01/88 (1.1%) 01/72 (1.4%) 1
PCR adjusted ACPR at day 28 85/88 (96.6%) 67/72 (93.1%) 0.55
% difference 0.3 [-3.3;3.9]  
PP analysis    
Early treatment failure 00 00 --
Crude Parasitological failure at day 28 01/86 (1.2%) 01/68 (1.5%) 1
PCR adjusted failure rate at day 28 01/86 (1.2%) 01/68 (1.5%) 1
PCR adjusted ACPR at day 28 85/86 (98.8%) 67/68 (98.5%) 0.87
% difference 0.3 [-3.3;3.9]  
Ivory Coast (160 patients) 80 80  
ITT analysis    
Early treatment failure 00 00 --
Crude Parasitological failure at day 28 02/80 (2.5%) 04/80 (2.5%) 0.68
PCR adjusted failure rate at day 28 01/80 (1.3%) 02/80 (2.5%) 1
PCR adjusted ACPR at day 28 79/80 (98.8%) 77/80 (96.3%) 0.36
% difference 2.5 [-0.9;5.9]  
PP analysis    
Early treatment failure 00 00  
Crude Parasitological failure at day 28 02/79 (2.5%) 04/79 (5.1%) 0.68
PCR adjusted failure rate at day 28 01/79 (1.2%) 02/79 (2.5%) 1
PCR adjusted ACPR at day 28 79/79 (100%) 77/79 (97.5%) 0.16
% difference 2.5 [0.9;5.6]  
Cameroun (161 patients) 81 80  
ITT analysis    
Early treatment failure 00 00  
Crude Parasitological failure at day 28 02/81 (2.5%) 04/80 (5%) 0.66
PCR adjusted failure rate at day 28 02/81 (2.5%) 04/80 (5%) 0.66
PCR adjusted ACPR at day 28 79/81 (97.5%) 76/80 (95%) 0.40
% difference, 95%CI 2.5% [-3.3;8.4]  
PP analysis    
Early treatment failure 00 00 --
Crude Parasitological failure at day 28 02/81 (2.5%) 04/80 (5%) 0.66
PCR adjusted failure rate at day 28 02/81 (2.5%) 04/80 (5%) 0.66
PCR adjusted ACPR at day 28 79/81 (97.5%) 76/80 (95%) 0.40
% difference 2.5% [-3.3;8.4]