Table 4 Treatment outcome stratified by country
Treatment outcome stratified by country | Artesunate/Amodiaquine | Artemether/Lumefantrine | p value |
|---|---|---|---|
Senegal (160 patients) | 80 | 80 | |
ITT analysis | |||
Early treatment failure | 00 | 00 | -- |
Crude Parasitological failure at day 28 | 01/88 (1.1%) | 01/72 (1.4%) | 1 |
PCR adjusted failure rate at day 28 | 01/88 (1.1%) | 01/72 (1.4%) | 1 |
PCR adjusted ACPR at day 28 | 85/88 (96.6%) | 67/72 (93.1%) | 0.55 |
% difference | 0.3 [-3.3;3.9] | ||
PP analysis | |||
Early treatment failure | 00 | 00 | -- |
Crude Parasitological failure at day 28 | 01/86 (1.2%) | 01/68 (1.5%) | 1 |
PCR adjusted failure rate at day 28 | 01/86 (1.2%) | 01/68 (1.5%) | 1 |
PCR adjusted ACPR at day 28 | 85/86 (98.8%) | 67/68 (98.5%) | 0.87 |
% difference | 0.3 [-3.3;3.9] | ||
Ivory Coast (160 patients) | 80 | 80 | |
ITT analysis | |||
Early treatment failure | 00 | 00 | -- |
Crude Parasitological failure at day 28 | 02/80 (2.5%) | 04/80 (2.5%) | 0.68 |
PCR adjusted failure rate at day 28 | 01/80 (1.3%) | 02/80 (2.5%) | 1 |
PCR adjusted ACPR at day 28 | 79/80 (98.8%) | 77/80 (96.3%) | 0.36 |
% difference | 2.5 [-0.9;5.9] | ||
PP analysis | |||
Early treatment failure | 00 | 00 | |
Crude Parasitological failure at day 28 | 02/79 (2.5%) | 04/79 (5.1%) | 0.68 |
PCR adjusted failure rate at day 28 | 01/79 (1.2%) | 02/79 (2.5%) | 1 |
PCR adjusted ACPR at day 28 | 79/79 (100%) | 77/79 (97.5%) | 0.16 |
% difference | 2.5 [0.9;5.6] | ||
Cameroun (161 patients) | 81 | 80 | |
ITT analysis | |||
Early treatment failure | 00 | 00 | |
Crude Parasitological failure at day 28 | 02/81 (2.5%) | 04/80 (5%) | 0.66 |
PCR adjusted failure rate at day 28 | 02/81 (2.5%) | 04/80 (5%) | 0.66 |
PCR adjusted ACPR at day 28 | 79/81 (97.5%) | 76/80 (95%) | 0.40 |
% difference, 95%CI | 2.5% [-3.3;8.4] | ||
PP analysis | |||
Early treatment failure | 00 | 00 | -- |
Crude Parasitological failure at day 28 | 02/81 (2.5%) | 04/80 (5%) | 0.66 |
PCR adjusted failure rate at day 28 | 02/81 (2.5%) | 04/80 (5%) | 0.66 |
PCR adjusted ACPR at day 28 | 79/81 (97.5%) | 76/80 (95%) | 0.40 |
% difference | 2.5% [-3.3;8.4] | ||