Figure 2
From: Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii
Effect of 17-AAG and 17-PEG-Alkyn-GA treatment on parasite growth and mortality of P. yoelii 17 XL infected mice. Four groups (A-D) of mice were injected with ~106 P. yoelii 17 XL infected mouse red blood cells and parasitemia was monitored every day. On days 6th and 12fth post-infection, mice were injected with: (A) 10% DMSO (control) (â–²); (B) 300 nMoles of 17-AAG dissolved in 10% DMSO (â– ); (C) 300 nMoles of 17-PEG-Alkyn-GA dissolved in 10% DMSO (â—‹); (D) 300 nMoles of chloroquine (in water and was injected on day 6th only) (x); (E) average percent parasitemia for the four groups and (F) survival profile. There were 4 animals (n = 4) in each group.