Table 3 Single marker results of allelic and genotypic association with placental malaria
From: Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria
Allelic associations | Genotypic association | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Gene | SNP | Mutation | All. freq cases | All. freq controls | P-value | Permuted P -value | Odds ratio | 95% CI | Best genotypic model | Empirical p -value |
MBL2 | rs1800451 | G57E | 0.36 | 0.26 | 0.014 | 0.014 | 1.60 | 1.10-2.32 | Dominant | 0.021 |
MASP2 | rs12085877 | H439R | 0.11 | 0.19 | 0.014 | 0.020 | 0.55 | 0.34-0.89 | Allelic | 0.015 |
MASP2 | rs1033638 | 3'UTR | 0.36 | 0.27 | 0.04 | 0.022 | 1.52 | 1.01-2.26 | Trend | 0.064 |
FCN2 | rs3128624 | Intron 2 | 0.67 | 0.62 | 0.198 | 0.204 | 1.27 | 0.88-1.81 | Dominant | 0.053 |
FCN2 | rs7037264 | Intron 3 | 0.68 | 0.64 | 0.271 | 0.261 | 1.23 | 0.85-1.76 | Dominant | 0.042 |
CFP | rs909523 | Intron 6 | 0.57 | 0.47 | 0.019 | 0.029 | 1.51 | 1.07-2.13 | Trend | 0.043 |