Table 4 Association of different phenotypes of P.falciparum placental malaria with mutations MBL2*G57E and MASP2*R439H
From: Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria
MBL2*G57E (MBL2*C; rs1800451) | MASP2*R439H (rs12085877) | |||||||
|---|---|---|---|---|---|---|---|---|
Wildtype (GG) | Mutation (AA or AG) | p-value | OR | Wildtype (CC) | Mutation (TT or TC) | p-value | OR | |
Placental malaria | 45.5% (56/123) | 60.7% (88/145) | 0.014 | 1.84 (1.13-3.01) | 57.7% (113/196) | 43.8% (32/73) | 0.054 | 0.58 (0.33-0.99) |
Maternal peripheral blood | ||||||||
PCR positive | 53.7% (66/123) | 63.4% (92/145) | 0.108 | 1.50 (0.92-2.45) | 62.2% (122/196) | 49.3% (36/73) | 0.070 | 0.59 (0.34-1.02) |
Microscopy positive | 24.8% (29/117) | 29.0% (40/138) | 0.482 | 28.9% (55/190) | 22.7% (15/66) | 0.423 | ||
Placental blood | ||||||||
PCR positive | 60.2% (74/123) | 70.3% (102/145) | 0.094 | 1.57 (0.94-2.61) | 68.4% (134/196) | 58.9% (43/173) | 0.151 | |
Microscopy positive | 39.0% (48/123) | 54.5% (79/145) | 0.014 | 1.86 (1.15-3.05) | 49.0% (96/196) | 41.1% (30/73) | 0.218 | |
Haemozin pigments present | 36.9% (45/122) | 48.3% (70/145) | 0.064 | 1.59 (0.98-2.62) | 48.0% (94/196) | 29.2% (21/72) | 0.008 | 0.47 (0.26-0.83) |
Low birth weight | 27.0% (33/122) | 24.1% (35/145) | 0.673 | 28.6% (56/196) | 16.7% (12/72) | 0.057 | 0.51 (0.24-0.99) | |
Maternal anaemia | 35.0% (43/123) | 40.7% (59/145) | 0.378 | 38.8% (76/196) | 35.6% (26/73) | 0.673 | ||
Preterm birth | 27.0% (33/122) | 23.4% (34/145) | 0.571 | 23.5% (46/196) | 29.2% (21/72) | 0.344 | ||