Table 4 Peroxidative degradation of haemin at pH 5
Compound | Unchanged haemin (%) | ||
|---|---|---|---|
30 min | 60 min | ||
Negative control | Water | 98 ± 6.0a | 93 ± 5.9 |
MeOH/DMSO | 98 ± 1.0 | 97 ± 1.3 | |
Positive control | Water | 45 ± 7.0 | 36 ± 5.3 |
MeOH/DMSO | 41 ± 6.2* | 33 ± 4.5 | |
Chloroquine | 53 ± 10.6 | 45 ± 8.5 | |
Mefloquine | 48 ± 9.1 | 39 ± 7.2 | |
(R)-1 | 46 ± 7.3 | 39 ± 4.9 | |
(S)-1 | 47 ± 7.8 | 40 ± 5.0 | |
(R)-2 | 63 ± 2.8** | 48 ± 3.6*** | |
(S)-2 | 63 ± 4.1** | 49 ± 3.8† | |
(R)-3 | 73 ± 2.4‡ | 60 ± 2.7‡ | |
(S)-3 | 73 ± 2.0‡ | 59 ± 2.9‡ | |
(R)-4 | 50 ± 12.7 | 45 ± 12.7 | |
(S)-4 | 49 ± 12.1 | 45 ± 11.1 | |
(R)-5 | 49 ± 11.1 | 44 ± 11.3 | |
(S)-5 | 50 ± 13.5 | 45 ± 14.3 | |
(R)-6 | 71 ± 2.6$ | 57 ± 3.9£ | |
(S)-6 | 70 ± 4.6$ | 56 ± 4.5£ | |