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Table 1 In vitro activity (IC50 in μM) of tested drugs on Plasmodium falciparum in MCF7 and Vero cells

From: Biological activities of nitidine, a potential anti-malarial lead compound

Cell lines

Nitidine

Chloroquine

Doxorubicin

F32

0.52 ± 0.1

0.051

NT

FcB1

0.80 ± 0.28

0.141

NT

FcM29

0.49 ± 0.1

0.22

NT

RIa

1.55 and 0.95

4.3

 

MCF-7

0.23 ± 0.03

> 50

0.42 ± 0.05

Vero

8.16 ± 1.04

> 50

6.4 ± 0.9

SIb

0.74 and 26.3

  
  1. a: Resistance index: F32/FcB1 and F32/FcM29
  2. b: Selectivity index: FcB1/McF7 and FcB1/Vero