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Table 1 Relationship between antibodies levels and drug efficacy in treatment of uncomplicated P.falciparum malaria

From: Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso

Antigens IgG Type CQ SP
   Protected GM*(95%CI) N Unprotected GM*(95%CI) N P P* Protected GM*(95%CI) N Unprotected GM*(95%CI) N P P*
MSP3 IgG 3.55(3.31-3.78) 16 3.18 (3.12-3.25) 179 0.001 0.78 3.42(3.17-3.66) 20 3.26(3.09-3.43) 33 0.27 0.79
  IgM 1.34(1.16-1.53) 16 1.32(1.19-1.45) 179 0.91 0.53 1.48(1.06-1.90) 20 1.40(1.06-1.73) 33 0.75 0.73
  IgG1 0.98(0.53-1.44) 16 0.44(0.37-0.52) 179 0.001 0.22 0.58(0.23-0.94) 20 0.56(0.27-0.84) 33 0.89 0.25
  IgG2 0.42(0.23-0.61) 16 0.21(0.18-0.25) 179 0.001 0.19 0.29(0.13-0.44) 20 0.18(0.13-0.23) 33 0.09 0.69
  IgG3 1.31(0.64-1.99) 16 0.84(0.67-1.01) 179 0.12 0.48 1.35(0.67-2.04) 20 0.67(0.37-0.97) 33 0.03 0.35
  IgG4 0.04(0.01-0.09) 16 0.01(0.008-0.01) 179 0.01 0.29 0.03(0.001-0.08) 20 0.01(0.006-0.02) 33 0.32 0.91
MSP1-19 IgG 3.25(2.85-3.65) 16 3.19(3.10-3.28) 179 0.69 0.72 3.11(2.92-3.31) 20 3.22(3.01-3.44) 33 0.47 0.46
  IgM 1.12(0.85-1.39) 16 1.25(1.16-1.34) 179 0.41 0.01 1.53(1.20-1.85) 20 1.30(1.09-1.50) 33 0.19 0.77
  IgG1 1.67(0.95-2.38) 16 1.38(1.23-1.53) 179 0.27 0.50 1.38(0.98-1.78) 20 1.20(0.87-1.52) 33 0.47 0.29
  IgG2 0.28(0.16-0.40) 16 0.23(0.19-0.27) 179 0.43 0.02 0.22(0.14-0.31) 20 0.19(0.14-0.24) 33 0.48 0.73
  IgG3 0.85(0.54-1.16) 16 0.62(0.54-0.70) 179 0.12 0.85 0.63(0.45-0.81) 20 0.47(0.34-0.60) 33 0.14 0.18
  IgG4 0.03(0.002.0.07) 16 0.03(0.009-0.06) 179 0.95 0.61 0.005(-0.001-0.01) 20 0.04(0.003-0.07) 33 0.14 0.13
GLURP IgG 3.91(3.43-4.39) 16 3.48(3.38-3.58) 179 0.01 0.68 3.58(3.33-3.82) 20 3.47(3.24-3.70) 33 0.54 0.68
  IgM 2.20(1.14-2.99) 16 0.97(0.86-1.08) 179 0.001 0.02 1.08(0.82-1.33) 20 0.87(0.68-1.05) 33 0.17 0.89
  IgG1 1.39(0.96-1.81) 16 1.05(0.92-1.17) 179 0.13 0.77 1.10(0.77-1.43) 20 1.20(0.84-1.56) 33 0.69 0.36
  IgG2 0.68(0.48-0.88) 16 0.46(0.38-0.54) 179 0.11 0.76 0.54(0.29-0.79) 20 0.50(0.29-0.72) 33 0.82 0.65
  IgG3 0.77(0.59-0.94) 16 0.64(0.57-0.71) 179 0.32 0.34 0.72(0.50-0.94) 20 0.59(0.48-0.71) 33 0.24 0.63
  IgG4 0.006(-0.003-0.16) 16 0.02(-0.002-0.05) 179 0.57 0.30 0.04(-0.03-0.12) 20 0.02(-0.002-0.05) 33 0.63 0.83
  1. N: number of children, GM*: geometric mean of Ig; P: P value not adjusted for age and sex, P*: P value adjusted for age and sex.