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Table 1 Relationship between antibodies levels and drug efficacy in treatment of uncomplicated P.falciparum malaria

From: Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso

Antigens

IgG Type

CQ

SP

  

Protected

GM*(95%CI)

N

Unprotected

GM*(95%CI)

N

P

P*

Protected

GM*(95%CI)

N

Unprotected

GM*(95%CI)

N

P

P*

MSP3

IgG

3.55(3.31-3.78)

16

3.18 (3.12-3.25)

179

0.001

0.78

3.42(3.17-3.66)

20

3.26(3.09-3.43)

33

0.27

0.79

 

IgM

1.34(1.16-1.53)

16

1.32(1.19-1.45)

179

0.91

0.53

1.48(1.06-1.90)

20

1.40(1.06-1.73)

33

0.75

0.73

 

IgG1

0.98(0.53-1.44)

16

0.44(0.37-0.52)

179

0.001

0.22

0.58(0.23-0.94)

20

0.56(0.27-0.84)

33

0.89

0.25

 

IgG2

0.42(0.23-0.61)

16

0.21(0.18-0.25)

179

0.001

0.19

0.29(0.13-0.44)

20

0.18(0.13-0.23)

33

0.09

0.69

 

IgG3

1.31(0.64-1.99)

16

0.84(0.67-1.01)

179

0.12

0.48

1.35(0.67-2.04)

20

0.67(0.37-0.97)

33

0.03

0.35

 

IgG4

0.04(0.01-0.09)

16

0.01(0.008-0.01)

179

0.01

0.29

0.03(0.001-0.08)

20

0.01(0.006-0.02)

33

0.32

0.91

MSP1-19

IgG

3.25(2.85-3.65)

16

3.19(3.10-3.28)

179

0.69

0.72

3.11(2.92-3.31)

20

3.22(3.01-3.44)

33

0.47

0.46

 

IgM

1.12(0.85-1.39)

16

1.25(1.16-1.34)

179

0.41

0.01

1.53(1.20-1.85)

20

1.30(1.09-1.50)

33

0.19

0.77

 

IgG1

1.67(0.95-2.38)

16

1.38(1.23-1.53)

179

0.27

0.50

1.38(0.98-1.78)

20

1.20(0.87-1.52)

33

0.47

0.29

 

IgG2

0.28(0.16-0.40)

16

0.23(0.19-0.27)

179

0.43

0.02

0.22(0.14-0.31)

20

0.19(0.14-0.24)

33

0.48

0.73

 

IgG3

0.85(0.54-1.16)

16

0.62(0.54-0.70)

179

0.12

0.85

0.63(0.45-0.81)

20

0.47(0.34-0.60)

33

0.14

0.18

 

IgG4

0.03(0.002.0.07)

16

0.03(0.009-0.06)

179

0.95

0.61

0.005(-0.001-0.01)

20

0.04(0.003-0.07)

33

0.14

0.13

GLURP

IgG

3.91(3.43-4.39)

16

3.48(3.38-3.58)

179

0.01

0.68

3.58(3.33-3.82)

20

3.47(3.24-3.70)

33

0.54

0.68

 

IgM

2.20(1.14-2.99)

16

0.97(0.86-1.08)

179

0.001

0.02

1.08(0.82-1.33)

20

0.87(0.68-1.05)

33

0.17

0.89

 

IgG1

1.39(0.96-1.81)

16

1.05(0.92-1.17)

179

0.13

0.77

1.10(0.77-1.43)

20

1.20(0.84-1.56)

33

0.69

0.36

 

IgG2

0.68(0.48-0.88)

16

0.46(0.38-0.54)

179

0.11

0.76

0.54(0.29-0.79)

20

0.50(0.29-0.72)

33

0.82

0.65

 

IgG3

0.77(0.59-0.94)

16

0.64(0.57-0.71)

179

0.32

0.34

0.72(0.50-0.94)

20

0.59(0.48-0.71)

33

0.24

0.63

 

IgG4

0.006(-0.003-0.16)

16

0.02(-0.002-0.05)

179

0.57

0.30

0.04(-0.03-0.12)

20

0.02(-0.002-0.05)

33

0.63

0.83

  1. N: number of children, GM*: geometric mean of Ig; P: P value not adjusted for age and sex, P*: P value adjusted for age and sex.
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Malaria Journal

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