Uncomplicated Plasmodium falciparum malaria in infants <5 kg: retrospective surveillance of hospital records in five Sub-Saharan African countries
© Alao et al; licensee BioMed Central Ltd. 2012
Published: 15 October 2012
WHO recommends artemisinin-based combination therapy (ACT) as first-line therapy for infants >5 kg of body weight (BW) with uncomplicated P. falciparum malaria. No ACTs are indicated in infants <4.5 kg. Coartem® (20 mg artemether-120 mg lumefantrine, AL), with an available pediatric formulation, has a large clinical trial and postmarketing safety experience in infants ≥5 kg. Published reports on malaria in younger infants are scanty, leaving a significant knowledge gap about the pattern and outcome of malaria in this sub-population. The aim of the current study was to collect data on the clinical features, treatment and outcomes of uncomplicated P. falciparum malaria in infants <5kg in five countries within Sub-Saharan Africa.
Materials and methods
Hospital charts ranging from 2006-2011 from eight hospitals in Bénin, Burkina Faso, the Democratic Republic of Congo, Nigeria, and Togo were retrospectively reviewed for inpatient and outpatient neonates and infants weighing <5 kg with parasitologically confirmed diagnosis of uncomplicated P. falciparum malaria. Details of clinical features, patient age group (<1 month or >1 month), treatment type received, and clinical outcomes were collected, and a descriptive analysis of data was carried out. A total of 907 cases were identified for inclusion.
The annual disease incidence ranged from 12 to 120 cases across hospitals and calendar years. There was a higher proportion of infants in the younger age group in Burkina Faso, Nigeria, and Togo, but in Bénin and the DRC the opposite was true. In all countries, the most frequent reason for seeking care was fever. Other reasons included dyspnea, cough or vomiting. Parasite density was generally low (<10% of the infants presented with parasitemia >5000/µL). In all countries other than Togo, quinine was the most common treatment (66% of patients overall). The second most common treatment overall was an ACT (22% of cases). The vast majority of patients recovered from their illness following treatment.
Malaria in infants weighing <5 kg exists in Sub-Saharan Africa and calls for appropriate treatment. A prospective, multicenter, open-label study is currently planned to assess clinical efficacy, safety and pharmacokinetics of AL dispersible tablet in the treatment of acute uncomplicated P. falciparum malaria in infants <5 kg. Study results are expected in 2014.
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