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Table 2 Statistics of the 15 STR loci of Plasmodium falciparum -positive individuals: mutants to PYR

From: Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea

Microsatellites Sampled populations - Miyobo Sampled populations - Ngonamanga
Single mutant Double mutant Triple mutant All samples Triple mutant
( N=10) (N=37) (N=17) (N=64) (N=82)
R s H e R s H e R s H e R s H e F ST P R s H e
Loci flanking dhfr gene Dhfr 0.3 3 0.51 3 0.32 2 0.15 3 0.33 0.02 NS 7 0.26
Dhfr 4.4 1 0.00 2 0.14 2 0.17 2 0.10 -0.04 NS 3 0.10
Dhfr 5.3 3 0.56 2 0.18 1 0.00 2 0.24 0.10 0.03 3 0.08
All loci 2 0.36 2 0.21 2 0.11 2 0.22 0.03 0.05 4 0.15
Neutral loci TA1 4 0.82 5 0.83 6 0.89 6 0.85 0.04 0.04 12 0.87
TA102 4 0.64 7 0.88 5 0.84 6 0.79 0.03 NS 8 0.78
ARA2 4 0.69 5 0.77 6 0.79 5 0.75 -0.03 NS 9 0.81
TA87 4 0.87 6 0.85 5 0.81 6 0.84 0.01 NS 9 0.84
PfPK2 5 0.93 6 0.86 5 0.85 6 0.88 -0.03 NS 12 0.87
TA81 4 0.87 5 0.81 4 0.71 5 0.80 -0.04 NS 10 0.87
TA42 3 0.60 2 0.11 2 0.28 2 0.32 0.06 NS 8 0.36
Pfg377 3 0.67 3 0.56 3 0.65 3 0.62 -0.04 NS 7 0.55
TA109 5 0.86 5 0.80 4 0.79 5 0.82 0.04 0.03 8 0.75
  All loci 4 0.77 5 0.72 4 0.73 5 0.74 <0.01 NS 9 0.74
  1. N: number of isolates genotyped, He: expected heterozygosity; Rs: allelic richness. All loci: mean over loci Rs and He and global Fst over loci as calculated by FSTAT. P: P- values of permutation tests to assess significance of Fst values. NS: non-significant (P>0.05).