Prevalence of molecular markers of drug resistance in an area of seasonal malaria chemoprevention in children in Senegal

Table 2 Prevalence of resistance mutations in 2008 among those typed and estimated prevalence in the population

	Study samples		Prevalence in population^$
	Control area	SMC area	Control area	SMC area	Prevalence ratio^	p-value
					SMC/ non SMC (95% CI)
Prevalence of parasitaemia:	66/1686	18/1019	4.86	1.46	0.30 (0.15, 0.61)	0.001
Prevalence of mutations
dhfr triple (51, 59, 108)	27/37	7/8	2.88	1.55	0.54 (0.25, 1.17)	0.12
dhps-437	25/37	7/8	2.68	1.55	0.58 (0.25, 1.34)	0.20
SP resistant mutant (dhfr triple + dhps 437)	23/37	6/8	2.47	1.32	0.54 (0.22, 1.30)	0.17
crt CVIET mutation	8/35	2/3	0.87	1.18	1.36 (0.39, 4.71)	0.63
mdr 86Y	0/19	1/5	0	0.35	-	-
mdr 184F	13/19	4/5	2.74	1.41	0.52 (0.23, 1.14)	0.10
AQ resistant mutant (mdr 86Y + crt CVIET)	0/13	1/2	0	0.88	-	-
SP resistant & AQ resistant	0/11	1/2	0	0.88	-	-

^ Prevalence ratios accounting for survey design. $For genotypes, prevalence among population is estimated as the product of 1) the probability of a resistant genotype among the typed samples and 2) the probability positive among samples with a definitive result (positive or negative) for asexual stage parasitaemia. Standard errors estimated by the delta method as described in the methods section.

ISSN: 1475-2875