Figure 5

Nimodipine improves ECG parameters and did not worse hypotension in ECM mice. Heart rate variation (A) of ECM mice treated with either nimodipine or vehicle via IP injection or slow continuous delivery using osmotic pumps. PR interval (B), heart rate variability (HRV, C), HF power spectral band (D), and LF power spectral band (E) variation from baseline of ECM mice submitted to the same treatment schemes as in A. Except for A, values were measured before and 30 min after treatment in all groups. Diastolic (F), mean (G) and systolic (H) arterial pressures variation of uninfected and ECM mice treated with either nimodipine or vehicle given via osmotic pumps. Vertical dotted line indicates the moment of infection. Nimodipine was used at 4 mg/kg when used IP and at 0.5 mg/kg/day when used via an osmotic pump. n ≥4 mice per group. *p<0.05, **p<0.01, ***p<0.001, # indicates that mean is significantly different from baseline (horizontal dashed lines). DAP= diastolic arterial pressure; MAP= mean arterial pressure; SAP= systolic arterial pressure.