Intra-host dynamics with refined gametocytaemia. A) As Figure 1A with parameters described in Methods. B) As compared to Figure 1B, gametocytes are not just assumed to be proportional to merozoites but their longevity is incorporated – according to Equations (5) and (6) respectively. The grey shaded area indicates a period of isolation in which no transmission can occur, and is only relevant for figure D. C) as Figure 1C but fitness is derived from Figure 2B and (7). D) As in Figure C, but the two-day isolation (indicated in grey in Figure B) according to equation (8) is taken into account. Hence, the gametocytaemia dynamics in the grey shaded area are disregarded for the derivation of fitness.