Figure 2

Alignment of PHIST domains from PHISTa family members. The PHISTa domains of all P. falciparum PHISTa family members were aligned using MUSCLE[27] and edited using Jalview[28]. Residues are coloured according to the standard CLUSTAL colour scheme: blue indicates a majority of hydrophobic amino acids at a given residue, red indicates a majority of basic amino acids, magenta indicates a majority of acidic amino acids, green indicates a majority of N, S, T or Q, and G and P are coloured regardless of conservation. The two tryptophan residues that are conserved in most PHIST domains are marked by closed circles.