Figure 4

Some clinically observable properties of mature gametocytes if gametocytes unaffected by acquired immunity. Immature and mature gametocytes unaffected by host acquired immunity response. The color code used in each panel is the same as for Figure 3. (A) Plot of maximum blood density of mature gametocytes, Max _MG , versus maximum density of intracellular asexual forms, Max _Asx for simulated P. falciparum infections. The simulations were binned by the logarithm of Max _Asx , and horizontal bars show the width of each bin. The logarithmic average of Max _MG are computed for each bin for each of the four types of models color coded. Only simulations that produced mature gametocytes are included, and results are only shown for bins that contained 10 or more simulations. (B) Same as (A), except for simulated P. vivax infections. (C) Plot of ratio of duration of mature gametocytes in the host Dur _MG to duration of asexual forms Dur _Asx versus Dur _Asx for simulated P. falciparum infections. The simulations were binned by the logarithm of Dur _Asx , and horizontal bars show the width of each bin. The logarithmic average of Dur _MG /Dur _Asx are computed for each bin for each of the four types of models color coded. Only simulations that produced mature gametocytes are included, and results are only shown for bins that contained 10 or more simulations. (D) Same as (C), except for simulated P. vivax infections.