Figure 2
Models used to describe AM, LF, MQ and PPQ and active metabolites DHA and DLF. For AM and LF, CL = (k 20 – k 23 ) × V C , with k 20  = CL/V C . Because of problems of identification of k 23 , V M and CL met , V M was assumed to equal V C . The concentration at baseline (C 0 ) was fitted by using a dummy dose of 1 mg times the estimated parameter F 0 (see text). AM: artemether; AS: artesunate; DHA: dihydroartemisinin; DLF: desbutyl-lumefantrine; LF: lumefantrine; MQ: mefloquine; PPQ: piperaquine.