Models used to describe AM, LF, MQ and PPQ and active metabolites DHA and DLF. For AM and LF, CL = (k
) × V
, with k
. Because of problems of identification of k
was assumed to equal V
. The concentration at baseline (C
) was fitted by using a dummy dose of 1 mg times the estimated parameter F
(see text). AM: artemether; AS: artesunate; DHA: dihydroartemisinin; DLF: desbutyl-lumefantrine; LF: lumefantrine; MQ: mefloquine; PPQ: piperaquine.