Concentration-time simulations of lumefantrine. A: Predicted median concentration of lumefantrine after administration of 6 × 480 mg (adults) regimen over 3 (continuous line) and 5 days (dotted line). Day 7 (168 h) median predicted concentrations (circles) with their 95% prediction intervals are shown for the two dosage regimens. B: Predicted mean (95% C.I.) time (estimated from time of last dose to 168 h) at which concentrations lie below the cut-off values of 50 ng/ml (rhombi), 175 ng/ml (triangles) and 280 ng/ml (squares). Full and empty symbols associated with continuous and dotted lines represent 6-dose regimens over 3 and 5 days respectively.