Effect of baseline parasitaemia on IC
values for drugs tested by HRP-2 ELISA. (A) DHA, (B) AS, (C) MQ, (D) PPQ, (E) QN, and (F) CQ. Results presented are IC50 values for drugs against W2 and D6 strains obtained from 2 independent experiments. The Kruskal–Wallis test was utilized to compare IC50 values when testing a range of parasitaemias from 0.005 to 0.5% for W2 parasites and from 0.05 to 0.5% for D6 parasites. Red stars indicate significant p-values and reduced IC50 values compared to those attained from a 0.5% parasitaemia baseline (p < 0.05 by Dunn’s Multiple comparison). Black circles and blue squares indicate IC50 values against W2 and D6, respectively. The dashed line in each graph indicates low baseline parasitaemia (<0.2%).