Figure 8

Comparison of amino acid and nucleotide sequences of the circumsporozoite post repeat 3′ terminal region. Key differences linked to vk210 or vk247 CR types are shown. The csp primary structure indicating the interspecies: conserved RI and RII, white boxes. CRR, central repeat region. The variable 3′ terminal region (3′V) between CR region and the conserved domain GQGQ of the csp gene is shown; points indicate absence of nucleotide variation. The dashed lines indicate absence of the fragment. The synonymous and non-synonymous nucleotide changes are indicated by lower and upper case letters respectively. Amino acid substitutions are separated by a slash. Other csp sequences of Sal I strain (X_M001613018), Brazil (DQ978648.1), Belem strain (M11926.1), Korean (DQ156137.1) and Colombian isolates ColS2 (JN689932.1); ColLb (JN689933.1) are indicated as reference. In parenthesis two identical fragments of 57 nucleotide, including last codon of Gly or Ala residue†, are indicated. Nd, no determined. Sm, Southern Mexican isolates. Nicaraguan isolates: Nir1, Nir2, Nichn and Nichg.