Analysis of IgG subclass in responders to ICB2-5. Differences in subclasses levels were assessed between groups. A) IgG3 levels against ICB2-5 of individuals from PCR+/M-; PCR+/M + and PCR-/M- were compared by one-way non-parametric Kruskal-Wallis test (first panel) to assess differences between groups. Analysis to assess which group the levels of IgG3 were different was performed by non-parametric Dunn's test for multiple comparisons (second panel). The significant differences (p < 0.05) were identified as letters “a” or “b”, intermediate level of antibodies was “ab”. The same analyses were performed for other subclasses levels against ICB2-5: B) IgG2; C) IgG1 and D) IgG4.