Fas and Fas ligand expression. A. Micrographs showing the expression of Fas in pyramidal neurons of representative examples of (from left): an uninfected mouse, an untreated Plasmodium berghei-infected mouse (inf.), and a P. berghei-infected mouse treated with Azadirachta indica crude extract. B. Effect of A. indica on the expression of Fas (upper) and Fas ligand (lower) in pyramidal neurons of P. berghei-infected mice. Note the significant decrease in expression of both molecules following treatment with chloroquine (chlor.), artemether (artem.), and A. indica extract (more marked at dose 1,000 mg/kg). Data are mean ± SEM.