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Table 3 Number and prevalence of SP resistance-associated haplotypes in pfdhfr and pfdhps in Pakistan, by province

From: A comprehensive survey of polymorphisms conferring anti-malarial resistance in Plasmodium falciparum across Pakistan

  

Number and prevalence (%) of pfdhfr, pfdhps, andpfdhfr + pfdhps alleles

  

pfdhfr N51I + C59R + S108N

pfdhfr N51I + S108N

pfdhfr C59R + S108N

pfdhps A437G + K540E

pfdhfr C59R + S108N + pfdhps A437G

 

n

Mixed*

Pure**

Pure

Mixed

Pure

Mixed

Pure

Mixed

Balochistan

33

4 (12)

1 (3)

26 (79)

1 (3)

2 (6)

16 (49)

19 (58)

0

KPK***

91

0

2 (2)

87 (95)

1 (1)

1 (1)

32 (35)

46 (51)

1 (1)

Islamabad

2

0

0

2 (100)

0

0

2 (100)

2 (1)

0

Punjab

43

3 (7)

8 (19)

31 (72)

1 (2)

1 (2)

25 (58)

19 (44)

5 (12)

Sindh

2

0

0

2 (100)

0

0

2 (100)

2 (100)

0

Total

171

7 (4)

11 (6)

148 (87)

3 (2)

4 (2)

77 (45)

88 (52)

6 (4)

  1. *Mixed pfdhfr N51I + S108N not detected.
  2. **Pure pfdhfr triple mutant not detected.
  3. ***KPK: Khyber Pakhtunkhwa.