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Table 3 Number and prevalence of SP resistance-associated haplotypes in pfdhfr and pfdhps in Pakistan, by province

From: A comprehensive survey of polymorphisms conferring anti-malarial resistance in Plasmodium falciparum across Pakistan

   Number and prevalence (%) of pfdhfr, pfdhps, andpfdhfr + pfdhps alleles
   pfdhfr N51I + C59R + S108N pfdhfr N51I + S108N pfdhfr C59R + S108N pfdhps A437G + K540E pfdhfr C59R + S108N + pfdhps A437G
  n Mixed* Pure** Pure Mixed Pure Mixed Pure Mixed
Balochistan 33 4 (12) 1 (3) 26 (79) 1 (3) 2 (6) 16 (49) 19 (58) 0
KPK*** 91 0 2 (2) 87 (95) 1 (1) 1 (1) 32 (35) 46 (51) 1 (1)
Islamabad 2 0 0 2 (100) 0 0 2 (100) 2 (1) 0
Punjab 43 3 (7) 8 (19) 31 (72) 1 (2) 1 (2) 25 (58) 19 (44) 5 (12)
Sindh 2 0 0 2 (100) 0 0 2 (100) 2 (100) 0
Total 171 7 (4) 11 (6) 148 (87) 3 (2) 4 (2) 77 (45) 88 (52) 6 (4)
  1. *Mixed pfdhfr N51I + S108N not detected.
  2. **Pure pfdhfr triple mutant not detected.
  3. ***KPK: Khyber Pakhtunkhwa.