Figure 6

Quantitative trait analysis for survival phenotype. Quantitative trait locus analysis was performed on 149 F2 mice with 343 markers. A. Shown are the LOD scores plotted against 343 genetic markers on all chromosomes for all 149 F2 mice (black), for 80 males (blue) and 69 females (pink). The dotted lines indicate p value cut offs based on permutation testing of the data. B. Lod score profile for chromosome 9 and location of berr9 (green). C. Positions of loci char1, char10, and pymr that are associated with control of malaria resistance on chromosome 9 [17, 24, 25, 43]. Regions with genetic differences between FVB/NJ and DBA/2J mice are indicated as grey lines at the bottom of the graph (from Perlegen Mouse SNP Browser [44]).