Malaria Journal

Table 2 Summary of drug interactions ^a

From: Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis

	IC₅₀-Based		LD₅₀-Based
Combination	HB3 (CQS)	Dd2 (CQR)	HB3 (CQS)	Dd2 (CQR)
CQ-PQ	Antagonistic	Additive	Antagonistic	Antagonistic
CQ-TQ	Antagonistic	Antagonistic	-	-
CQ-AQ	Additive	Additive	Additive	Antagonistic
CQ-MB	Antagonistic	Antagonistic	-	-
AQ-PQ	Antagonistic	Antagonistic	-	-
AQ-TQ	Additive	Antagonistic	-	-
AQ-MB	Antagonistic	Antagonistic	-	-
PQ-MB	Antagonistic	Additive	-	-
TQ-MB	Additive	Synergistic	Synergistic	Synergistic

^aAntagonism is defined by a convex isobologram curve (FIC_index > 1), additivity by a isobologram curve along the diagonal (FIC_index = 1), and synergy by a concave isobologram curve (FIC_index < 1) (Figure 2).

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ISSN: 1475-2875

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