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Table 1 Plasmodium falciparum false-negative diagnoses by the HRP2-based test

From: Pfhrp2 and pfhrp3 polymorphisms in Plasmodium falciparum isolates from Dakar, Senegal: impact on rapid malaria diagnostic tests

  Palutop+4® Microscopy RT-PCR HRP2a HRP3b
Identification Pan Pf Pv Diagnostic Parasitaemia Pf Pv   
186/1 + + Pf 0.5% +
212/1 Pf 0.02% + + (B)
55/2 Pf 0.5% + + (B)
56/3 Pf 0.5% + +
150/3 Pf 0.001% +
157/3 c   + + (B)
183/3 Pf 0.004% + + (C)
  1. Pf = Plasmodium falciparum; Pv = Plasmodium vivax; RT-PCR = real-time polymerase chain reaction.
  2. a − If deletion of pfhrp2 and + if presence of pfhrp2.
  3. (B) Group B, sensitive to PfHRP2, detection, number of type 2 repeats × type 7 repeats between 50 to 100 repeats.
  4. (C) Group C, non sensitive PfHRP2 detection, number of type 2 repeats × type 7 repeats < 43 repeats.
  5. b − If deletion of pfhrp3 and + if presence of pfhrp3.
  6. c Thin and thick blood smears were negative.