Table 1 Activity data for anti-malarial drugs
From: Identification of inhibitors of Plasmodium falciparum gametocyte development
COMPOUND | 3D7a | NF54-pfs16-GFPa | NF54-pfs16-GFPb | (I-III)/ABS | (IV-V)/ABS |
|---|---|---|---|---|---|
ABS | early (I-III) gam | late (IV-V) gam | |||
4-Aminoquinolines | |||||
Amodiaquine | 255 (65) | 242 (110) | 87% | 0.9 | |
Naphthoquines | 411 (82) | 483 (330) | NA | 1.2 | |
AQ-13 | 183 (0.01) | 453 (230) | 82% | 2.5 | |
Piperaquines | 1880 (210) | 3990 (2800) | 43% | 1.6 | |
Hydroxychloroquines | 966 (130) | 1340 (140) | 45% | 1.4 | |
Pyronaridine | 299 (69) | 250 (96) | 4260 (240) | 0.8 | 14.2 |
8-Aminoquinolines | |||||
Pamaquine | 88% | 79% | NA | ||
Primaquine | 7120 (1500) | NA | 74% | ||
Tafenoquine | 5650 (1600) | 4800 (1500) | 4620 (1600) | 0.8 | 0.8 |
NPC-1161B | 3360 (860) | 2180* | 4850 (2700) | 0.6 | 1.4 |
Endoperoxides | |||||
Artemether | 25.8 (11) | 11 (2.8) | 3.13 (0.7) | 0.4 | 0.1 |
Artenimol (DHA) | 2.08 (0.6) | 18.3 (17) | 2.17 (1.2) | 8.8 | 1.0 |
Artesunate | 6.7 (1.6) | 3.8 (0.28) | 2.53 (1.10) | 0.6 | 0.4 |
Artemisinin | 41.6 (12) | 12.1 (14) | 5.47 (2.0) | 0.3 | 0.1 |
Artemisone | 3.72 (0.14) | 2.4 (0.85) | 1.7 (0.46) | 0.6 | 0.5 |
Anti folates | |||||
Pyrimethamine | 21.5 (0.07) | NA | NA | ||
Chlorproguanil | 6250 (520) | 108% | 4340 (840) | 0.7 | |
Proguanil HCl | 78% | 6540* | 84% | ||
Dapsone | NA | NA | NA | ||
Sulphonamides | |||||
Sulfadiazine | NA | NA | NA | ||
Sulfamethoxazole | NA | NA | NA | ||
Sulfadoxine | NA | NA | NA | ||
Amino alcohols | |||||
Halofantrine | 136 (66) | 135 (98) | 31.9 (11) | 1.0 | 0.2 |
Lumefantrines | 137 (70) | 107 (137) | 2.07 (0.55) | 0.8 | 0.0 |
Mefloquine (Racemic) | 158 (33) | 223 (120) | 100 (3.6) | 1.4 | 0.6 |
Mefloquine (+ RS) | 133 (41) | 226 (76) | 134 (110) | 1.7 | 1.0 |
Quinine sulfate | 217 (0.7) | 2110 (280) | 318 (180) | 9.7 | 1.5 |
Antibiotics | |||||
Trimethoprim | 3740 (120) | NA | NA | ||
Thiostrepton | 913 (210) | 959 (570) | 556 (58) | 1.1 | 0.6 |
Clindamycin | 325 (64) | NA | NA | ||
Cis-mirincamycin (HCl) | NA | NA | 64% | ||
Trans-mirincamycin (HCl) | 86% | NA | 66% | ||
Tetracycline | 2270 (170) | NA | NA | ||
Other | |||||
Fosmidomycin mono sodiums | 91% | NA | NA | ||
Methylene blue trihydrate | 21.9 (0.07) | 280 (130) | 287 (100) | 12.8 | 13.1 |
Pentamidine | 697 (36) | 1560 (620) | 2850 (540) | 2.2 | 4.1 |