Thapsigargin combined with: | P. falciparum strains | +(∑FIC) ± Standard error at different ratio of drug combinations | |||||||
---|---|---|---|---|---|---|---|---|---|
1:3 | 1:1 | 3:1 | |||||||
∑FIC50 | ∑FIC90 | ∑FIC50 | ∑FIC90 | ∑FIC50 | ∑FIC90 | mean ∑FIC50* | mean ∑FIC90* | ||
OZ277 | K1 | 1.0 ± 0.0 | 1.0 ± 0.1 | 1.1 ± 0.0 | 1.1 ± 0.1 | 1.4 ± 0.1 | 1.4 ± 0.1 | 1.2 | 1.2 |
NF54 | 1.0 ± 0.1 | 1.0 ± 0.0 | 1.2 ± 0.1 | 0.9 ± 0.0 | 1.1 ± 0.1 | 0.9 ± 0.0 | 1.1 | 0.9 | |
Artemether | K1 | 1.2 ± 0.2 | 1.1 ± 0.0 | 1.1 ± 0.0 | 1.0 ± 0.1 | 1.1 ± 0.1 | 0.9 ± 0.1 | 1.1 | 1.0 |
NF54 | 1.1 ± 0.1 | 1.0 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.0 | 1.2 ± 0.1 | 1.0 ± 0.0 | 1.1 | 1.0 | |
Artesunate | K1 | 1.2 ± 0.0 | 1.2 ± 0.0 | 1.2 ± 0.1 | 1.2 ± 0.2 | 1.3 ± 0.0 | 1.1 ± 0.1 | 1.2 | 1.2 |
NF54 | 1.1 ± 0.0 | 1.0 ± 0.0 | 1.1 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.0 | 1.0 ± 0.1 | 1.1 | 1.0 |