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Table 1 Summary of anti-malarial alkaloids derived from the African flora – indoles, naphthoisoquinolines and furoquinolines

From: The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids

Compound subclass

Isolated metabolites

Plant species (Family)

Part of plant studied

Place of harvest (locality, country)

Author, reference

Indole alkaloids

1, 2, 3, 4, 5, 6 and 7

Monodora angolensis (Annonaceae)

Stem and root bark

Kiwanda, Tanzania

Nkunya et al.[47]

8 and 9

Isolona cauliflora (Annonaceae)

Stem and root bark, and flower stalks

Namikwe Island, Tanzania

Nkunya et al.[47]

10

Strychnos usambarensis (Loganiaceae)

Leaves

Akagera National Park, Rwanda

Cao et al.[48]

11 and 12

Penianthus longifolius (Menispermaceae)

Stem bark

Cameroon

Bidla et al.[49]

13

Glossocalyx brevipes (Siparunaceae)

Leaves

Kumba, Cameroon

Mbah et al. [50]

14

Fagara zanthoxyloides (Rutaceae)

Roots

Nigeria

Odebiyi et al.[51]

15

Picralima nitida (Apocynaceae)

Fruits

Nnewi, Nigeria

Okunji et al.[52]

16

Strychnos usambarensis (Loganiaceae)

Roots

Akagera National Park, Rwanda

Frédérich et al.[55]

17, 18 and 19

Strychnos usambarensis (Loganiaceae)

Leaves

Akagera National Park, Rwanda

Frédérich et al.[56]

Naphthoisoquinolines

20, 21, 22, 23 and 24

Ancistrocladus robertsoniorum (Acistrocladaceae)

Stems and leaves

Buda Mafisini Forest, Kenya

Bringmann et al.[57]

25, 26, 27, 28 and 29

Ancistrocladus tanzaniensis (Acistrocladaceae)

Leaves

Uzungwa Mountains, Tanzania

Bringmann et al.[58]

30

Triphyophyllum peltatum (Dioncophyllaceae)

Roots

Parc de Taï, West Ivory Coast

Bringmann et al.[59]

31

Triphyophyllum peltatum (Dioncophyllaceae)

Root bark

West Ivory Coast

Bringmann et al.[60]

32

Mixture of Triphyophyllum peltatum,aDioncophyllum tholloniib and Habropetalum daweic (Dioncophyllaceae)

Root and barka

West Ivory Coasta

Bringmann et al.[61]

Twigsb, c

Gabonb

 

Sierra Leonec

33, 34, 35 and 36

Triphyophyllum peltatum (Dioncophyllaceae)

Leaves and twigs

Mt. Nabemba, Congo Republica and

Bringmann et al.[6265]a

West Ivory Coastb

François et al. [66]b

Furoquinolines

37 and 38

Vepris uguenensis (Rutaceae)

Roots

Baringo District, Kenya

Cheplogoi et al.[68]

39 and 40

Toddalia asiatica (Rutaceae)

Roots

Ol Ari Nyiro Ranch, Kenya

Gakunju et al.[69]

41

Teclea gerrardii (Rutaceae)

Root bark

Durban, South Africa

Waffo et al.[70]

  1. a,b and ccorrespond to the respective references.