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Table 1 Summary of anti-malarial alkaloids derived from the African flora – indoles, naphthoisoquinolines and furoquinolines

From: The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids

Compound subclass Isolated metabolites Plant species (Family) Part of plant studied Place of harvest (locality, country) Author, reference
Indole alkaloids 1, 2, 3, 4, 5, 6 and 7 Monodora angolensis (Annonaceae) Stem and root bark Kiwanda, Tanzania Nkunya et al.[47]
8 and 9 Isolona cauliflora (Annonaceae) Stem and root bark, and flower stalks Namikwe Island, Tanzania Nkunya et al.[47]
10 Strychnos usambarensis (Loganiaceae) Leaves Akagera National Park, Rwanda Cao et al.[48]
11 and 12 Penianthus longifolius (Menispermaceae) Stem bark Cameroon Bidla et al.[49]
13 Glossocalyx brevipes (Siparunaceae) Leaves Kumba, Cameroon Mbah et al. [50]
14 Fagara zanthoxyloides (Rutaceae) Roots Nigeria Odebiyi et al.[51]
15 Picralima nitida (Apocynaceae) Fruits Nnewi, Nigeria Okunji et al.[52]
16 Strychnos usambarensis (Loganiaceae) Roots Akagera National Park, Rwanda Frédérich et al.[55]
17, 18 and 19 Strychnos usambarensis (Loganiaceae) Leaves Akagera National Park, Rwanda Frédérich et al.[56]
Naphthoisoquinolines 20, 21, 22, 23 and 24 Ancistrocladus robertsoniorum (Acistrocladaceae) Stems and leaves Buda Mafisini Forest, Kenya Bringmann et al.[57]
25, 26, 27, 28 and 29 Ancistrocladus tanzaniensis (Acistrocladaceae) Leaves Uzungwa Mountains, Tanzania Bringmann et al.[58]
30 Triphyophyllum peltatum (Dioncophyllaceae) Roots Parc de Taï, West Ivory Coast Bringmann et al.[59]
31 Triphyophyllum peltatum (Dioncophyllaceae) Root bark West Ivory Coast Bringmann et al.[60]
32 Mixture of Triphyophyllum peltatum,aDioncophyllum tholloniib and Habropetalum daweic (Dioncophyllaceae) Root and barka West Ivory Coasta Bringmann et al.[61]
Twigsb, c Gabonb
  Sierra Leonec
33, 34, 35 and 36 Triphyophyllum peltatum (Dioncophyllaceae) Leaves and twigs Mt. Nabemba, Congo Republica and Bringmann et al.[6265]a
West Ivory Coastb François et al. [66]b
Furoquinolines 37 and 38 Vepris uguenensis (Rutaceae) Roots Baringo District, Kenya Cheplogoi et al.[68]
39 and 40 Toddalia asiatica (Rutaceae) Roots Ol Ari Nyiro Ranch, Kenya Gakunju et al.[69]
41 Teclea gerrardii (Rutaceae) Root bark Durban, South Africa Waffo et al.[70]
  1. a,b and ccorrespond to the respective references.