Plasmodium falciparum parasitaemia was positively associated with IL-10 and negatively associated with IL-12p70 levels in the plasma of infected children. Mean plasma levels of (A) IL-10 and (B) IL-12p70 were determined by ELISA for each group (low (<1,000; n=51), medium (1,000-10,000; n=65) and high (>10,000; n=22) mean parasite density (per μl of blood) and compared to endemic controls (EC) (n=89). *, p ≤0.05; **, p ≤0.01 and ***, p ≤0.001 (ANOVA). Parasitaemia was plotted against (C) IL-10 and (D) IL-12p70 and association between variables was assessed using regression analysis. p <0.05 was deemed significant.