Figure 5

Malaria hemorrhages. Photomicrographs to demonstrate the histological characteristics of simple petechial haemorrhage (A) and a classical ring haemorrhage (B) in the brain tissues of a case of cerebral malaria. The simple petechial haemorrhage shows a feeding vessel containing sequestered parasitized erythrocytes and an area of leakage of infected and uninfected erythrocytes into the brain parenchyma. In contrast the ring haemorrhage shows a central vessel (V), surrounded by a zone of clearing and astroglial response, with an outer zone of erythrocytes and leukocytes which have been extravasated from the ruptured vessel. Such haemorrhages may contain fibrin platelet thrombi in the vascular lumen (Haematoxylin and Eosin staining x400).