Table 5 Descriptive sub-group analysis of day-28 PCR-corrected ACPR for Plasmodium falciparum (intent-to-treat population)

Region

Asia

760/829

91.7 (89.8, 93.6)

310/344

90.1 (86.9, 93.3)

64/72

88.9 (81.5, 96.3)

Africa

1161/1223

94.9 (93.7, 96.2)

77/79

97.5 (93.9, 100)

496/531

93.4 (91.3, 95.5)

Age group, years

<5

145/159

91.2 (86.7, 95.6)

–

–

63/71

88.7 (81.2, 96.3)

5–12

621/656

94.7 (92.9, 96.4)

60/61

98.4 (95.1, 100)

255/274

93.1 (90.0, 96.1)

>12– <18

297/316

94.0 (91.4, 96.6)

52/53

98.1 (94.3, 100)

86/92

93.5 (88.3, 98.6)

≥18

858/921

93.2 (91.5, 94.8)

275/309

89.0 (85.5, 92.5)

156/166

94.0 (90.3, 97.6)

Gender

Male

1213/1301

93.2 (91.9, 94.6)

299/330

90.6 (87.4, 93.8)

293/315

93.0 (90.2, 95.8)

Female

708/751

94.3 (92.6, 95.9)

88/93

94.6 (90.0, 99.3)

267/288

92.7 (89.7, 95.7)

Weight, kg

<17

170/188

90.4 (86.2, 94.7)

–

–

84/94

89.4 (83.0, 95.7)

17– <25

385/401

96.0 (94.1, 97.9)

38/39

97.4 (92.2, 100)

159/171

93.0 (89.1, 96.8)

≥25

1366/1463

93.4 (92.1, 94.6)

349/384

90.9 (90.9, 93.8)

317/338

93.8 (91.2, 96.4)

Previous malaria

No

828/894

92.6 (90.9, 94.3)

199/220

90.5 (86.5, 94.4)

187/206

90.8 (86.8, 94.8)

Yes

1093/1157

94.5 (93.1, 95.8)

188/203

92.6 (89.0, 96.2)

373/397

94.0 (91.6, 96.3)

Malaria in last 12 months

None

976/1064

91.7 (90.1, 93.4)

232/258

89.9 (86.2, 93.6)

243/269

90.3 (86.8, 93.9)

1 episode

420/444

94.6 (92.5, 96.7)

84/92

91.3 (85.4, 97.2)

111/116

95.7 (92.0, 99.4)

>1 episode

519/537

96.6 (95.1, 98.2)

71/73

97.3 (93.4, 100)

203/215

94.4 (91.3, 97.5)

Baseline parasitaemia, μL ^-1

≤5000

487/521

93.5 (91.3, 95.6)

102/113

90.3 (84.7, 95.8)

150/161

93.2 (89.2, 97.1)

>5000–10,000

275/293

93.9 (91.1, 96.6)

64/72

88.9 (81.5, 96.3)

78/81

96.3 (92.1, 100)

>10,000

1159/1238

93.6 (92.3, 95.0)

221/238

92.9 (89.6, 96.2)

332/360

92.2 (89.4, 95.0)