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Table 3 Association between levels of antibodies (two-fold increment) at 5.5 months of age and the incidence of malaria up to 24 months of age

From: Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique

   5.5-24 months
Antigens Antibodies Crude Adjusted
   IRR1 95% CI P value2 IRR 95% CI P value
MSP-119 IgG 1.09 0.90; 1.33 0.3783 0.96 0.78; 1.17 0.6853
IgG1 1.10 0.90; 1.33 0.3525 0.96 0.79; 1.17 0.6872
IgG2 1.33 0.72; 2.45 0.3594 1.05 0.61; 1.83 0.8519
IgG3 1.20 0.87; 1.65 0.2508 0.93 0.67; 1.29 0.6599
IgG4 0.66 0.27; 1.60 0.3526 0.48 0.21; 1.14 0.0970
IgM 1.35 0.96; 1.89 0.0768 1.27 0.88; 1.85 0.2013
AMA-1 IgG 2.01 1.58; 2.56 < 0.0001 1.64 1.29; 2.09 < 0.0001
IgG1 1.81 1.48; 2.22 < 0.0001 1.54 1.25; 1.89 < 0.0001
IgG2 1.12 0.75; 1.66 0.5840 0.91 0.61; 1.36 0.6415
IgG3 1.38 1.05; 1.82 0.0169 1.15 0.89; 1.47 0.2803
IgG4 1.27 0.69; 2.33 0.4396 0.94 0.50; 1.78 0.8496
IgM 1.33 0.89; 2.00 0.1590 1.16 0.79; 1.70 0.4468
EBA-175 IgG 1.29 1.04; 1.60 0.0177 1.11 0.90; 1.37 0.3323
IgG1 1.36 1.08; 1.72 0.0077 1.21 0.97; 1.50 0.0916
IgG2 1.21 0.69; 2.12 0.4981 1.21 0.72; 2.04 0.4614
IgG3 1.34 0.97; 1.83 0.0701 1.20 0.89; 1.63 0.2324
IgG4 0.91 0.45; 1.82 0.7837 1.09 0.57; 2.07 0.7936
IgM 1.57 1.04; 2.38 0.0338 1.41 0.94; 2.12 0.0996
VSA IgG 1.42 1.10; 1.84 0.0069 1.55 1.19; 2.01 0.0008
  1. Analysis done by negative binomial regression models adjusted by treatment, season, neighbourhood, current infection, previous infection, maternal infection, congenital infection, placental inflammation, insecticide-treated bed net use, and indoor residual spraying.
  2. 1Incidence rate ratio.
  3. 2Negative binomial regression model using likelihood ratio test.