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Table 1 Anti-malarial drug parameters for artemether-lumefantrine (AM-LF) and dihydroartemisinin-piperaquine (DHA-PPQ) combination therapies

From: Optimizing the programmatic deployment of the anti-malarials artemether-lumefantrine and dihydroartemisinin-piperaquine using pharmacological modelling

Drug parameter

Artemether + lumefantrine

Dihydroartemisinin + piperaquine

 

AM

DHA

LF

DHA

PPQ

Vd (L/kg)

46.6 (82)

15 (48)

21 (263)

1.49 (48)

150 (42)

x (/day)

23.98 (68)

–

–

–

–

z (/day)

11.97 (65)

–

–

–

–

k (/day)

–

44.15 (23)

0.16 (5)

19.8 (23)

0.03 (54)

IC50 (mg/L)

0.0023 (79)

0.009 (117)

0.032 (102)

0.009 (117)

0.088 (30)

Vmax

27.6

27.6

3.45

27.6

3.45

n

4

4

4

4

6

  1. The means with associated variation (i e, coefficient of variation, CV) are given in brackets.
  2. Vd: volume of distribution; x: absorption rate constant; z: conversion rate constant; k: elimination rate constant; IC50: Concentration producing half the desired effect; Vmax: first-order rate constant of parasite killing; n: slope factor.
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Malaria Journal

ISSN: 1475-2875

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