Malaria Journal

Table 3 Percentage of individuals with mg/kg doses below or above the therapeutic dose range (according to [30]) of 1.4–4 mg/kg artemether (AM) and 10–16 mg/kg lumefantrine (LF) in each weight- and age-based dosing band

From: Optimizing the programmatic deployment of the anti-malarials artemether-lumefantrine and dihydroartemisinin-piperaquine using pharmacological modelling

Number of tablets		Age-based dosing regimen				Weight-based dosing regimen
		Global	Africa	Asia	Latin America	Global	Africa	Asia	Latin America
1 × 20/120 mg	n	1448	1448	1448	1063	2135	1848	2204	1455
	AM below	6.28%	9.32%	4.97%	5.93%	11.94%	11.53%	10.84%	10.45%
	AM above	0.07%	0.07%	0.21%	0.00%	0.00%	0.00%	0.00%	0.00%
	LF below	26.66%	31.63%	23.90%	27.85%	46.60%	43.99%	45.78%	43.44%
	LF above	11.05%	10.64%	11.53%	6.49%	7.35%	8.17%	8.35%	4.74%
2 × 20/120 mg	n	2781	2403	3216	2019	2497	2231	2585	1857
	AM below	2.45%	2.25%	2.52%	1.78%	0.00%	0.00%	0.00%	0.00%
	AM above	0.22%	0.17%	0.19%	0.00%	0.00%	0.00%	0.00%	0.00%
	LF below	8.45%	10.78%	8.86%	9.26%	7.13%	7.08%	6.42%	6.89%
	LF above	26.65%	20.06%	25.40%	21.15%	0.00%	0.00%	0.00%	0.00%
3 × 20/120 mg	n	1706	1270	1271	1147	1578	1307	1659	1206
	AM below	4.98%	1.81%	2.28%	3.05%	0.00%	0.00%	0.00%	0.00%
	AM above	0.18%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
	LF below	13.07%	9.06%	9.76%	10.99%	0.00%	0.00%	0.00%	0.00%
	LF above	17.76%	15.04%	11.49%	15.69%	0.00%	0.00%	0.00%	0.00%
4 × 20/120 mg	n	4065	4879	4065	5771	3790	4614	3552	5482
	AM below	8.83%	24.78%	2.44%	34.21%	9.55%	26.16%	2.48%	35.94%
	AM above	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
	LF below	26.17%	57.45%	14.42%	66.14%	28.94%	60.71%	17.23%	69.66%
	LF above	1.62%	2.46%	2.07%	2.41%	0.00%	0.00%	0.00%	0.00%

n: number of individuals in respective dosing band.

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ISSN: 1475-2875

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