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Figure 2 | Malaria Journal

Figure 2

From: Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections

Figure 2

Representative in vivo images (IVIS) of luminescence shown in the livers of live C57BL/6 albino mice at different time points after injection of 5 × 104sporozoites. Rainbow images show the relative levels of luminescence ranging from low (blue), to medium (green), to high (yellow/red). Luminescence levels (photons/sec) of livers in whole mice at 24, 48 and 72 hour time points following intragastric dosing daily for 3-consecutive-day on days -1, 0, 1, treated with tafenoquine (TQ) at a dose of 5 mg/kg (TQ, left) and vehicle control (VC, right) after sporozoite infection intravenously at day 0. Normally, P. berghei sporozoites reside in the mouse liver for 44–52 hours post-infection (n = 4).

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