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Table 6 Therapeutic efficacy of test compounds against Plasmodium falciparum Pf3D7 0087/N9 in a humanized mouse model

From: Repositioning: the fast track to new anti-malarial medicines?

Compound

Target dose (mg/kg)/route

ED50(mg/kg)

ED90(mg/kg)

AUCED90(μg · h · mL−1 · day−1)

UK-112,214

100, 300 po

80.1 (99.8, 55.1)

131.3 (112.3, 156.7)

111.5 (106.6, 121.1)

CEP-701

10, 30 sc

NC

NC

NC

CEP-1347

10, 30 sc

NC

NC

NC

PSC-833

50, 100, 200 po

–

>200

>17.33

  1. ED50 and ED90 values are shown as the mean (95% CI). Data was calculated to three decimal places.
  2. NC, not calculated as the percent reduction in parasitaemia was not significantly different from that of the control animals receiving vehicle only.
  3. sc, subcutaneous; po, oral administration.
  4. Study performed by GlaxoSmithKline.
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Malaria Journal

ISSN: 1475-2875

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