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Table 6 Therapeutic efficacy of test compounds against Plasmodium falciparum Pf3D7 0087/N9 in a humanized mouse model

From: Repositioning: the fast track to new anti-malarial medicines?

Compound Target dose (mg/kg)/route ED50(mg/kg) ED90(mg/kg) AUCED90(μg · h · mL−1 · day−1)
UK-112,214 100, 300 po 80.1 (99.8, 55.1) 131.3 (112.3, 156.7) 111.5 (106.6, 121.1)
CEP-701 10, 30 sc NC NC NC
CEP-1347 10, 30 sc NC NC NC
PSC-833 50, 100, 200 po >200 >17.33
  1. ED50 and ED90 values are shown as the mean (95% CI). Data was calculated to three decimal places.
  2. NC, not calculated as the percent reduction in parasitaemia was not significantly different from that of the control animals receiving vehicle only.
  3. sc, subcutaneous; po, oral administration.
  4. Study performed by GlaxoSmithKline.