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Table 3 Relapse incidence rates for the modified Macdonald system

From: Geographical variation in Plasmodium vivax relapse

Ecological zone Based on raw data, ML with 95% CI Model-based, REML with 95% CI
1 357 (CI: 318–400) 455 (CI: 313–662)
2 217 (CI: 198–238) 259 (CI: 120–557)
3 419 (CI: 328–528) 1093 (CI: 535–2,233)
5 + 6 214 (CI: 186–245) 262 (CI: 82–839)
7 221 (CI: 191–255) 213 (CI: 95–477)
8 25 (CI: 24–26) 62 (CI: 33–116)
9 + 10 975 (CI: 811–1163) 836 (CI: 351–1,995)
11 + 4 138 (CI: 120–159) 134 (CI: 64–278)
12 1023 (CI: 981–1,067) 1224 (CI: 689–2,174)
  1. The numbers are presented as first relapses per 100,000 person days. The estimate based on raw data is obtained by dividing the number of relapses by follow-up time and using Ulm’s exact formula [73] for confidence intervals. The model-based estimates are calculated from the results obtained from meta-analysis performed by the R package metafor. ML refers to the maximum likelihood and REML to restricted maximum likelihood.