Table 4 Sensitivity and specificity of combinations of symptoms for different clinical malaria definitions in children <5 years of age
A. Symptomatic P. falciparum parasitaemia | |||
Predictors | Rule | Sensitivity (%) | Specificity (%) |
Fever | Fever | 88. 9 | 15. 4 |
F, C, H, M, A | Any of F, C, H, M, A | 97. 2 | 5. 5 |
F, C, H, M | Any of F, C, H, M | 94. 4 | 8. 0 |
F, C, H | Any of F, C, H | 94. 4 | 8. 9 |
F, C | F or C | 88. 9 | 13. 4 |
F, H | F or H | 94. 4 | 9. 9 |
B. Symptomatic P. falciparum parasitaemia plus T ≥ 37.5°C | |||
Predictors | Rule | Sensitivity | Specificity |
Fever | Fever | 92. 0 | 11. 7 |
F, C, H, M, A | Any of F, C, H, M, A | 100. 0 | 5. 6 |
C, H, M, A | Any of C, H, M, A | 96. 0 | 25. 6 |
C, H, M | Any of C, H, M | 80. 0 | 55. 8 |
F, H | F or H | 100. 0 | 6. 5 |
C. Symptomatic P. falciparum parasitaemia ≥1,000parasites/μL plus T ≥ 37.5°C | |||
Predictors | Rule | Sensitivity | Specificity |
F | Fever | 100. 0 | 19. 3 |
F, H | F or H | 100. 0 | 13. 3 |
D. Symptomatic P. falciparum parasitaemia ≥4,000 parasites/μL plus T ≥ 37.5°C | |||
Predictors | Rule | Sensitivity | Specificity |
F | Fever | 100. 0 | 19. 5 |
F, H | F or H | 100. 0 | 13. 3 |