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Table 4 Sensitivity and specificity of combinations of symptoms for different clinical malaria definitions in children <5 years of age

From: Sensitivity of fever for diagnosis of clinical malaria in a Kenyan area of unstable, low malaria transmission

A. Symptomatic P. falciparum parasitaemia
Predictors Rule Sensitivity (%) Specificity (%)
Fever Fever 88. 9 15. 4
F, C, H, M, A Any of F, C, H, M, A 97. 2 5. 5
F, C, H, M Any of F, C, H, M 94. 4 8. 0
F, C, H Any of F, C, H 94. 4 8. 9
F, C F or C 88. 9 13. 4
F, H F or H 94. 4 9. 9
B. Symptomatic P. falciparum parasitaemia plus T ≥ 37.5°C
Predictors Rule Sensitivity Specificity
Fever Fever 92. 0 11. 7
F, C, H, M, A Any of F, C, H, M, A 100. 0 5. 6
C, H, M, A Any of C, H, M, A 96. 0 25. 6
C, H, M Any of C, H, M 80. 0 55. 8
F, H F or H 100. 0 6. 5
C. Symptomatic P. falciparum parasitaemia ≥1,000parasites/μL plus T ≥ 37.5°C
Predictors Rule Sensitivity Specificity
F Fever 100. 0 19. 3
F, H F or H 100. 0 13. 3
D. Symptomatic P. falciparum parasitaemia ≥4,000 parasites/μL plus T ≥ 37.5°C
Predictors Rule Sensitivity Specificity
F Fever 100. 0 19. 5
F, H F or H 100. 0 13. 3
  1. Abbreviations: F fever, C chills, H headache, M Malaise, A appetite.