Skip to main content

Table 3 Pharmacokinetics parameters of mefloquine in the present work and in previous studies

From: Population pharmacokinetics of mefloquine, administered as a fixed-dose combination of artesunate-mefloquine in Indian patients for the treatment of acute uncomplicated Plasmodium falciparum malaria

Parameter Gutmanet al.[19] Charleset al.[20] Ashleyet al.[21] Krudsoodet al.[18] Current study
Country of study Peru Australia Thailand Thai-Burmese border India
context uncomplicated falciparum malaria prophylaxis uncomplicated falciparum malaria uncomplicated falciparum malaria uncomplicated falciparum malaria
Age (yr): Mean (range)      
36 26 19 (Median) 27.8 28
18 - 61 18 - 55 2 - 55 16 - 50 18 -45
BW (kg)      
Mean NA 82 44.5 (Median) 51 53.3
Range NA 53 -135 10 - 63 40 - 65 40 - 70
CL/F 0.017 L/h/kg 2.09 L/h 1.33 L/h 0.024 L/h/kg 1.13 L/h
0.022 L/h/kg
V/F 8.57 L/kg 1011 L 488 L NA 615 L
11.9 L/kg
T1/2 14.5 days 14 days 10.5 days 13.4 days 21.6 days
  1. NA not available.