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Table 1 Inhibitory activities of lumefantrine, piperaquine, pyronaridine and atovaquone alone and in combination with atorvastatin against 13 strains of Plasmodium falciparum

From: In vitro interaction of lumefantrine and piperaquine by atorvastatin against Plasmodium falciparum

 Anti-malarial drugs     Lumefantrine     Piperaquine     Pyronaridine     Atovaquone
  IC50mean (nM) P-value IC50mean (nM) P-value IC50mean (nM) P-value IC50mean (μM) P-value
Alone 31.9 ± 15.1   61.1 ± 15.5   30.3 ± 9.6   3.79 ± 2.0  
+ 0.12 μM Atorvastatin 28.1 ± 15.1 0.0068 59.5 ± 19.7 NS 28.9 ± 9.2 NS 3.35 ± 1.5 NS
+ 0.25 μM Atorvastatin 26.3 ± 12.4 0.0019 61.7 ± 18.7 NS 29.1 ± 10.1 NS 3.35 ± 1.6 NS
+ 0.5 μM Atorvastatin 24.6 ± 11.7 0.0019 52.5 ± 17.5 0.0146 28.4 ± 10.2 NS 3.23 ± 1.3 NS
+ 1 μM Atorvastatin 20.5 ± 11.0 0.0009 51.2 ± 19.2 0.0244 26.9 ± 10.0 NS 2.93 ± 1.3 NS
  1. NS if P-value > 0.05.