Dissemination of malaria parasites in C57BL/6 wild-type (WT), CYP 2D knock-out, and humanized/CYP 2D6 knock-in mice 48 and 72 hr post-inoculation with luciferase expressing Plasmodium berghei in the absence or presence of NPC-1161B. A (i-v). IVIS images of various mouse strains 48 and 72 hr post-inoculation. The mice of each group tested are shown and the corresponding luminescence signal indicated. B. Quantitated luminescence signal for each group tested 48 and 72 hr post-inoculation.