Table 2 Geometric mean inhibitory concentration of various drugs against fresh P. falciparum isolates from Bangladesh
Antiplasmodial activity [nm] (95% CI) | |||
|---|---|---|---|
Drug (na)b | IC50(95% CI) | IC90(95% CI) | IC99(95% CI) |
MIR (n = 43) | 1,212.6 (703.9 – 2088.9) | 12,116.4 (6296.4 – 23 316.0) | 34,329.2 (18 895.1 – 62 370.2) |
CLI (n = 43) | 880.4 (469.7 – 1650.1) | 12,074.7 (6470.9 – 22 531.2) | 36,581.3 (24 386.7 – 54 873.9) |
AZM (n = 43) | 4,082.6 (2947.5 – 5654.8) | 21,781.4 (17 004.1 – 27 901.0) | 39,979.5 (26 901.2 – 59 415.9) |
DHA (n = 42) | 0.9 (0.7 – 1.1) | 2.9 (2.2 – 4.0) | 4.8 (3.3 – 6.9) |
CHL (n = 42) | 102.6 (78.0 –134.9) | 370.6 (279.1 – 492.1) | 651.2 (467.1 – 907.9) |
QNN (n = 42) | 61.2 (46.6 – 80.2) | 289.4 (236.2 – 354.7) | 538.5 (421.2 – 688.5) |
MEF (n = 42) | 13.6 (9.3 – 20.0) | 64.9 (47.1 – 89.3) | 272.7 (38.1 – 1953.9) |