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Table 2 Geometric mean inhibitory concentration of various drugs against fresh P. falciparum isolates from Bangladesh

From: Mirincamycin, an old candidate for malaria combination treatment and prophylaxis in the 21st century: in vitro interaction profiles with potential partner drugs in continuous culture and field isolates

Antiplasmodial activity [nm] (95% CI)
Drug (na)b IC50(95% CI) IC90(95% CI) IC99(95% CI)
MIR (n = 43) 1,212.6 (703.9 – 2088.9) 12,116.4 (6296.4 – 23 316.0) 34,329.2 (18 895.1 – 62 370.2)
CLI (n = 43) 880.4 (469.7 – 1650.1) 12,074.7 (6470.9 – 22 531.2) 36,581.3 (24 386.7 – 54 873.9)
AZM (n = 43) 4,082.6 (2947.5 – 5654.8) 21,781.4 (17 004.1 – 27 901.0) 39,979.5 (26 901.2 – 59 415.9)
DHA (n = 42) 0.9 (0.7 – 1.1) 2.9 (2.2 – 4.0) 4.8 (3.3 – 6.9)
CHL (n = 42) 102.6 (78.0 –134.9) 370.6 (279.1 – 492.1) 651.2 (467.1 – 907.9)
QNN (n = 42) 61.2 (46.6 – 80.2) 289.4 (236.2 – 354.7) 538.5 (421.2 – 688.5)
MEF (n = 42) 13.6 (9.3 – 20.0) 64.9 (47.1 – 89.3) 272.7 (38.1 – 1953.9)
  1. an, no. of fresh field isolates tested.
  2. bMIR, mirincamycin; CLI, clindamycin; AZM, azithromycin; DHA, dihydroartemisinin; CHL, chloroquine; QNN, quinine; MEF, mefloquine.