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Table 2 Genotype associations between selected SNP and syndromes of malaria

From: Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case–control study

Phenotype Gene SNPs Model Genotypes OR 95%CI P value
Anemia hHbS rs334 Heterozygous AT vs. AA/TT 0.50 0.31 0.80 0.004
GBP7 rs1803632 Heterozygous CG vs. GG/CC 1.42 1.05 1.91 0.023
CFTR rs17140229 Additive TT vs. CT vs. CC 0.78 0.62 0.97 0.026
NOS2 rs2297518 Heterozygous AG vs. AA/GG 0.49 0.35 0.70 6.32 × 10-5
GNAS rs8386 Heterozygous CT vs. TT/CC 0.67 0.47 0.95 0.024
G6PD(F) rs1050828 Dominant CT/TT vs. CC 2.47 1.34 4.56 0.003
G6PD(M) rs1050828 Recessive CC vs. CT/TT 3.01 1.26 7.18 0.009
G6PD(F) rs1050829 Dominant CT/TT vs. CC 1.88 1.20 2.93 0.005
CM CD40LG(F) rs3092945 Additive TT vs. CT vs. CC 4.03 1.19 13.79 0.021
CD40LG(M) rs3092945 Additive TT vs. CT vs. CC 4.03 1.18 13.79 0.021
Hyperparasitaemia GBP7 rs1803632 Dominant CG/CC vs. GG 0.53 0.29 0.96 0.041
ABO rs8176746 Heterozygous AC vs. AA/CC 0.41 0.18 0.93 0.019
NOS2 rs8078340 Heterozygous CT vs. CC/TT 1.80 1.01 3.21 0.046
DERL3 rs1128127 Recessive AA vs. GA/GG 0.45 0.21 0.98 0.029
Hyperpyrexia GBP7 rs1803632 Additive GG vs. CG vs. CC 0.73 0.55 0.99 0.042
CD36 rs3211938 Recessive GG vs. GT/TT 2.80 1.20 6.51 0.027
ABO rs8176746 Heterozygous AC vs. AA/CC 0.61 0.37 1.01 0.045
RTN3 rs542998 Additive TT vs. CT vs. CC 1.47 1.09 1.99 0.011
ADCY9 rs10775349 Additive CC vs. CG vs. GG 0.02 0.01 0.04 1.35 × 10-87
EMR1 rs373533 Heterozygous GT vs. GG/TT 1.86 1.22 2.84 0.003
EMR1 rs461645 Heterozygous CT vs. CC/TT 1.75 1.15 2.67 0.008
CD40LG(F) rs3092945 Dominant CT/CC vs. TT 1.96 1.01 3.83 0.044
G6PD(M) rs1050829 Recessive CC vs. CT/TT 1.84 1.06 3.20 0.033
SMA hHbS rs334 Heterozygous AT vs. TT/AA 0.34 0.13 0.93 0.024
ADCY9 rs2230739 Heterozygous AG vs. GG/AA 0.48 0.23 1.02 0.050
EMR1 rs461645 Recessive TT vs. CT/CC 2.05 1.12 3.75 0.020
UM NOS2 rs2297518 Heterozygous GA vs. GG/AA 0.50 0.29 0.84 0.007
NOS2 rs1800482 Recessive GG vs. GC/CC 7.94 1.06 59.50 0.043
EMR1 rs461645 Additive CC vs. CT vs. TT 1.42 1.04 1.93 0.025
  1. Additive, dominant, recessive and heterozygous advantage genotypic tests were performed, adjusted for age, sex, ethnicity and HbS, but only the most statistically significant result is presented. UM = uncomplicated malaria.