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Table 2 Genotype associations between selected SNP and syndromes of malaria

From: Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case–control study

Phenotype

Gene

SNPs

Model

Genotypes

OR

95%CI

P value‡

Anemia

hHbS

rs334

Heterozygous

AT vs. AA/TT

0.50

0.31

0.80

0.004

GBP7

rs1803632

Heterozygous

CG vs. GG/CC

1.42

1.05

1.91

0.023

CFTR

rs17140229

Additive

TT vs. CT vs. CC

0.78

0.62

0.97

0.026

NOS2

rs2297518

Heterozygous

AG vs. AA/GG

0.49

0.35

0.70

6.32 × 10-5

GNAS

rs8386

Heterozygous

CT vs. TT/CC

0.67

0.47

0.95

0.024

G6PD(F)

rs1050828

Dominant

CT/TT vs. CC

2.47

1.34

4.56

0.003

G6PD(M)

rs1050828

Recessive

CC vs. CT/TT

3.01

1.26

7.18

0.009

G6PD(F)

rs1050829

Dominant

CT/TT vs. CC

1.88

1.20

2.93

0.005

CM

CD40LG(F)

rs3092945

Additive

TT vs. CT vs. CC

4.03

1.19

13.79

0.021

CD40LG(M)

rs3092945

Additive

TT vs. CT vs. CC

4.03

1.18

13.79

0.021

Hyperparasitaemia

GBP7

rs1803632

Dominant

CG/CC vs. GG

0.53

0.29

0.96

0.041

ABO

rs8176746

Heterozygous

AC vs. AA/CC

0.41

0.18

0.93

0.019

NOS2

rs8078340

Heterozygous

CT vs. CC/TT

1.80

1.01

3.21

0.046

DERL3

rs1128127

Recessive

AA vs. GA/GG

0.45

0.21

0.98

0.029

Hyperpyrexia

GBP7

rs1803632

Additive

GG vs. CG vs. CC

0.73

0.55

0.99

0.042

CD36

rs3211938

Recessive

GG vs. GT/TT

2.80

1.20

6.51

0.027

ABO

rs8176746

Heterozygous

AC vs. AA/CC

0.61

0.37

1.01

0.045

RTN3

rs542998

Additive

TT vs. CT vs. CC

1.47

1.09

1.99

0.011

ADCY9

rs10775349

Additive

CC vs. CG vs. GG

0.02

0.01

0.04

1.35 × 10-87

EMR1

rs373533

Heterozygous

GT vs. GG/TT

1.86

1.22

2.84

0.003

EMR1

rs461645

Heterozygous

CT vs. CC/TT

1.75

1.15

2.67

0.008

CD40LG(F)

rs3092945

Dominant

CT/CC vs. TT

1.96

1.01

3.83

0.044

G6PD(M)

rs1050829

Recessive

CC vs. CT/TT

1.84

1.06

3.20

0.033

SMA

hHbS

rs334

Heterozygous

AT vs. TT/AA

0.34

0.13

0.93

0.024

ADCY9

rs2230739

Heterozygous

AG vs. GG/AA

0.48

0.23

1.02

0.050

EMR1

rs461645

Recessive

TT vs. CT/CC

2.05

1.12

3.75

0.020

UM

NOS2

rs2297518

Heterozygous

GA vs. GG/AA

0.50

0.29

0.84

0.007

NOS2

rs1800482

Recessive

GG vs. GC/CC

7.94

1.06

59.50

0.043

EMR1

rs461645

Additive

CC vs. CT vs. TT

1.42

1.04

1.93

0.025

  1. ‡Additive, dominant, recessive and heterozygous advantage genotypic tests were performed, adjusted for age, sex, ethnicity and HbS, but only the most statistically significant result is presented. UM = uncomplicated malaria.
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Malaria Journal

ISSN: 1475-2875

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