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Table 2 Investigated point mutations in pfmdr1, pfcrt and pvmdr1 genes

From: Return of chloroquine-sensitive Plasmodium falciparum parasites and emergence of chloroquine-resistant Plasmodium vivax in Ethiopia

   

Pfmdr1 locus

  

Pfcrt locus

 

Pvmdr1 locus

Codon position

86

184

1034

1042

1246

72

74

75

76

976

1076

Wild type/Mutant

TGA/TGT

ATA/ATT

CAG/CT G

TTA/TTG

GAG/GAT

TGT/A GT

ATG/ATT

AAT/G AA

AAA/AC A

TAC/TT C

TTT/C TT

ns substitution

Asn/Tyr

Tyr/Phe

Ser/Cys

Asn/Asp

Asp/Tyr

Cys/Ser

Met/Ile

Asn/Glu

Lys/Thr

Tyr/Phe

Phe/Leu

  1. ns: non synonymous ; pfmdr1: Plasmodium falciparum multi-drug resistance 1; pfcrt: Plasmodium falciparum chloroquine resistance transporter; pvmdr1: Plasmodium vivax multi-drug resistance 1.
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Malaria Journal

ISSN: 1475-2875

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