Skip to main content

Advertisement

Table 2 Investigated point mutations in pfmdr1, pfcrt and pvmdr1 genes

From: Return of chloroquine-sensitive Plasmodium falciparum parasites and emergence of chloroquine-resistant Plasmodium vivax in Ethiopia

    Pfmdr1 locus    Pfcrt locus   Pvmdr1 locus
Codon position 86 184 1034 1042 1246 72 74 75 76 976 1076
Wild type/Mutant TGA/TGT ATA/ATT CAG/CT G TTA/TTG GAG/GAT TGT/A GT ATG/ATT AAT/G AA AAA/AC A TAC/TT C TTT/C TT
ns substitution Asn/Tyr Tyr/Phe Ser/Cys Asn/Asp Asp/Tyr Cys/Ser Met/Ile Asn/Glu Lys/Thr Tyr/Phe Phe/Leu
  1. ns: non synonymous ; pfmdr1: Plasmodium falciparum multi-drug resistance 1; pfcrt: Plasmodium falciparum chloroquine resistance transporter; pvmdr1: Plasmodium vivax multi-drug resistance 1.