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Table 2 Comparison of the results obtained with the diagnostic methods on the 177 whole blood samples

From: The development of loop-mediated isothermal amplification targeting alpha-tubulin DNA for the rapid detection of Plasmodium vivax

Assay No. positive No. negative Sensitivity (95% CId) Specificity (95% CI) PPVa(95% CI) NPVb(95% CI) % agreement with nested PCR (Kappa) AUCc(95% CI)
Microscopy 96 81 75.0 (66.8-81.7) 100 (91.1-100) 100 (95.3-100) 60.5 (49.6-70.4) 81.9 (0.624) 0.875 (0.817–0.920)
RDT 137 40 93.0 (87.9–96.4) 63.3 (49.2–75.3) 86.9 (80.1–91.6) 77.5 (62.2–87.8) 84.7 (0.596) 0.781 (0.713–0.840)
Nested PCR 128 49       
α-tubulin LAMP 137 40 100 (96.4-100) 81.6 (68.3-90.2) 93.4 (87.8-96.6) 100 (89.3-100) 94.9 (0.865) 0.908 (0.856–0.946)
  1. The sensitivities and specificities of the tests were determined using the nested PCR results as gold standard.
  2. aPPV, positive predictive value, bNPV, negative predictive value, cAUC, area under the receiver operating characteristic curve, dCI, confidence interval.