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Table 4 Association analysis* for the clinical phenotypes

From: Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali

   Association analysis
Alleles Dogon Fulani
SNP, gender Ref Alt Comparison OR (95% CI) P-value OR (95% CI) P-value
Any malaria
 rs915941, female C A Recessive A 3.193 (1.365, 7.468) 0.0060 0.734 (0.418, 1.289) 0.2785
 rs915942, female G A Dominance A 0.278 (0.130, 0.595) 0.0002 0.163 (0.016, 1.604) 0.0763
 rs2515905, female G A Additive A 9.136 (1.262, 66.163) 0.0052 0.165 (0.019,1.459) 0.0533
 rs1050828, female G A Additive A 3.108 (1.295, 7.460) 0.0077 ND 0.0691
 rs61042368, male G A A vs. G 0.744 (0.256, 2.159) 0.5843 8.845 (1.474, 53.069) 0.0065
 rs2230036, male C T T vs. C 0.701 (0.225, 2.185) 0.5376 8.819 (1.469, 52.954) 0.0066
 rs73573478, male G A A vs. G 0.692 (0.214, 2.233) 0.5347 8.488 (1.413, 50.984) 0.0077
Asymptomatic malaria
 rs915942, female G A Additive A 0.379 (0.212, 0.676) 0.0005 0.544 (0.270, 1.098) 0.0803
 rs2515905, female G A Additive A 10.672 (1.447, 78.724) 0.0071 0.448 (0.103, 1.947) 0.2412
Clinical malaria
 rs915942, female G A Dominance A 0.151 (0.041, 0.554) 0.0030 1.924 (0.582, 6.486) 0.0587
 rs61042368, male G A A vs. G 0.465 (0.122, 1.766) 0.2451 24.948 (1.951, 319.05) 0.0051
 rs2230036, male C T T vs. C 0.552 (0.142, 2.151) 0.3805 21.919 (1.713, 280.40) 0.0069
 rs73573478, male G A A vs. G 0.542 (0.134, 2.185) 0.3775 20.851 (1.637, 265.67) 0.0078
Parasite positivity
 rs915941, female C A Recessive A 4.512 (1.755, 11.600) 0.0014 1.161 (0.507, 2.658) 0.7229
 rs915942, female G A Dominance A 0.185 (0.077, 0.445) 0.0001 0.178 (0.018, 1.803) 0.0996
 rs1050828, female G A Additive A 4.089 (1.626, 10.279) 0.0019 ND 0.0315
  1. ND = not determined because of low sample size, *adjusted for age and season.
  2. P-values less than 0.008 are bolded.