Table 5 Possible adverse events (AE) found in patients included in the study on thiamin treatment and Plasmodium falciparum malaria in Laos*

At least one adverse event

226/630 (36%)

101/314 (32%)

125/316 (40%)

0.053

Headache

33/438 (7.5%)

18/219 (8%)

15/219 (7%)

0.58

Insomnia

36/629 (6%)

15/313 (5%)

21/316 (7%)

0.32

Weakness

33/629 (5%)

15/313 (5%)

18/316 (6%)

0.61

Anorexia

35/629 (6%)

15/313 (5%)

20/316 (6%)

0.40

Diarrhoea

31/630 (5%)

10/314 (3%)

21/316 (7%)

0.04

Nightmare

17/439 (4%)

5/219 (2%)

12/220 (5%)

0.08

Abdominal pain

12/447 (3%)

6/221 (3%)

6/226 (3%)

0.97

Dizziness

12/438 (3%)

4/219 (2%)

8/219 (4%)

0.24

Vomiting

14/629 (2%)

4/313 (1%)

10/316 (3%)

0.10

Nausea

5/440 (1%)

2/221 (1%)

3/219 (1%)

0.65

Palpitation

5/439 (1%)

1/220 (0.5%)

4/219 (2%)

0.17

Itch

5/629 (1%)

2/313 (1%)

3/316 (1%)

0.66

Vertigo

1/438 (0.2%)

0

1/219 (0.5%)

0.32

Tinnitus

1/440 (0.2%)

0

1/220 (0.45%)

0.32

Rash

1/629 (0.2%)

1/313 (0.3%)

0

0.31

Urticaria

1/629 (0.2%)

0

1/316 (0.3%)

0.32

Irritability

0

0

0

-

Dyspnoea

1/629 (0.2%)

1/313 (0.3%)

0

0.31

Hearing loss

0

0

0

-

Paraesthesia

2/441 (0.5%)

1/221 (0.5%)

1/220 (0.5%)

0.99