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Table 3 TNF (-308G > A) and IL-6 (-176G > C) polymorphisms and outcome of vivax malaria infection: first series of participants from Rondonia, Brazil

From: DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outcomes of patients with Plasmodium vivax malaria

  Genotype χ2 Allele frequency χ2 GG vs GA + AA χ2
  GG n (%) GA n (%) AA n (%) G (%) A (%)
TNF-308 polymorphism         
Uninfected (n = 77) 60 (77.92) 15 (19.48) 2 (2.60) 2.12 p = 0.7134# 135 (87.66) 19 (12.34) 0.57 p = 0.7509 0.96 p = 0.6178
Asymptomatic malaria (n = 104) 78 (75.00) 25 (24.04) 1 (0.96) 181 (87.02) 27 (12.98)
Mild malaria (n = 76) 54 (71.05) 21 (27.63) 1 (1.32) 129 (84.87) 23 (15.13)
Infected vs uninfected     p = 0.3401*#    p = 0.6745* P = 0.5316*
Mild vs asymptomatic     p = 0.6059*#    p = 4798* P = 0.4323*
Asymptomatic vs uninfected     p = 0.5866*#    p = 8749* P = 0.7252*
  Genotype χ2 Allele frequency χ2 GG vs GC + CC χ2
  GG n (%) GC n (%) CC n (%) G (%) C (%)
IL6-176 polymorphism         
Uninfected (n = 77) 49 (63.64) 23 (29.87) 5 (6.49) 2.16 p = 0.7058 121 (78.57) 33 (21.43) 1.61 p = 0.4462 1.91 p = 0.3854
Asymptomatic malaria (n = 104) 60 (57.69) 38 (36.54) 6 (5.77) 158 (75.96) 50 (24.04)
Mild malaria (n = 76) 40 (52.63) 30 (39.47) 6 (7.90) 110 (72.37) 42 (27.63)
Infected vs uninfected     1.56 p = 0.4579    p = 0.3695* p = 0.2702*
Mild vs asymptomatic     1.30 p = 0.5214    p = 0.2618* p = 0.2711*
Asymptomatic vs uninfected     0.88 p = 0.6435    p = 0.0819* p = 0.4458*
  1. *In these cases, Fisher exact test was used. #Analysis excluded genotype AA. χ2: coefficient and P value measured using Chi-square test. Infected individuals represent symptomatic plus asymptomatic cases.