Table 3 TNF (-308G > A) and IL-6 (-176G > C) polymorphisms and outcome of vivax malaria infection: first series of participants from Rondonia, Brazil

TNF-308 polymorphism

Uninfected (n = 77)

60 (77.92)

15 (19.48)

2 (2.60)

2.12 p = 0.7134^#

135 (87.66)

19 (12.34)

0.57 p = 0.7509

0.96 p = 0.6178

Asymptomatic malaria (n = 104)

78 (75.00)

25 (24.04)

1 (0.96)

181 (87.02)

27 (12.98)

Mild malaria (n = 76)

54 (71.05)

21 (27.63)

1 (1.32)

129 (84.87)

23 (15.13)

Infected vs uninfected

p = 0.3401*^#

p = 0.6745*

P = 0.5316*

Mild vs asymptomatic

p = 0.6059*^#

p = 4798*

P = 0.4323*

Asymptomatic vs uninfected

p = 0.5866*^#

p = 8749*

P = 0.7252*

Genotype

χ2

Allele frequency

χ2

GG vs GC + CC χ2

GG n (%)

GC n (%)

CC n (%)

G (%)

C (%)

IL6-176 polymorphism

Uninfected (n = 77)

49 (63.64)

23 (29.87)

5 (6.49)

2.16 p = 0.7058

121 (78.57)

33 (21.43)

1.61 p = 0.4462

1.91 p = 0.3854

Asymptomatic malaria (n = 104)

60 (57.69)

38 (36.54)

6 (5.77)

158 (75.96)

50 (24.04)

Mild malaria (n = 76)

40 (52.63)

30 (39.47)

6 (7.90)

110 (72.37)

42 (27.63)

Infected vs uninfected

1.56 p = 0.4579

p = 0.3695*

p = 0.2702*

Mild vs asymptomatic

1.30 p = 0.5214

p = 0.2618*

p = 0.2711*

Asymptomatic vs uninfected

0.88 p = 0.6435

p = 0.0819*

p = 0.4458*