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Table 4 DDX39B polymorphisms (-22C > G and -348C > T) and outcome of vivax malaria infections: first series of participants from Rondonia, Brazil

From: DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outcomes of patients with Plasmodium vivax malaria

  Genotype χ2 Allele frequency χ2 CC vs CG + GG χ2
  CC n (%) CG n (%) GG n (%) C (%) G (%)
DDX39B-22 polymorphism         
Uninfected (n = 77) 10 (12.99) 38 (49.35) 29 (37.66) 6.75 p = 0.1496 58 (37.66) 96 (62.34) 2.35 p = 0.3088 0.53 p = 0.7660
Asymptomatic malaria (n = 104) 15 (14.42) 64 (61.54) 25 (24.04) 94 (45.19) 114 (54.81)
Mild malaria (n =7 6) 13 (17.10) 34 (44.74) 29 (38.16) 60 (39.47) 92 (60.53)
Infected vs uninfected     1.48 p = 0.4758    p = 0.3281* p = 0.2460*
Mild vs asymptomatic     2.90 p = 0.2339    p = 0.6244* p = 0.7028*
Asymptomatic vs uninfected     3.98 p = 0.1364    p = 0.1625* p = 0.8307*
  Genotype   Allele frequency   CC vs TC + TT χ2
  CC n (%) TC n (%) TT n (%)   C (%) T (%)  
DDX39B-348 polymorphism         
Uninfected (n = 77) 64 (83.12) 12 (15.58) 1 (1.30) 1.99 p = 0.3691# 140 (90.91) 14 (9.09) 1.00 p = 0.6041 1.56 p = 0.4586
Asymptomatic malaria (n = 104) 83 (79.81) 21 (20.19) 0 (0.00) 187 (89.90) 21 (10.10)
Mild malaria (n = 76) 57 (75.00) 19 (25.00) 0 (0.00) 133 (87.50) 19 (12.50)
Infected vs uninfected     p = 0.2397*#    p = 0.5342* p = 0.4012*
Symptomatic vs asymptomatic     p = 0.2372*#    p = 0.3469* p = 0.3108*
Asymptomatic vs uninfected     p = 0.5594*#    p = 0.8578* p = 0.7008*
  1. *In these cases, Fisher exact test was used. #Analysis excluded genotype TT. χ2: coefficient and P value measured using Chi-square test. Infected individuals represent symptomatic plus asymptomatic cases.