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Figure 1 | Malaria Journal

Figure 1

From: Chitinase 3-like 1 is induced by Plasmodium falciparum malaria and predicts outcome of cerebral malaria and severe malarial anaemia in a case–control study of African children

Figure 1

Plasma CHI3L1 levels are increased in children with severe malaria and are predictive of outcome. (A) CHI3L1 was measured by ELISA in the plasma of Ugandan children presenting to Mulago Hospital with uncomplicated malaria (UM, n = 53), cerebral malaria (CM, n = 44), and severe malarial anaemia (SMA, n = 59). (B) CM and SMA patients were analyzed based on the outcome of infection (i.e., survival versus fatality). CM and SMA were examined separately (left side), then pooled together (right side) for further analysis. Data are presented as dot plots with medians. **p < 0.01 and ***p < 0.001, Kruskal-Wallis test with Dunn’s post-hoc tests. (C) Receiver operating characteristic (ROC) curve analysis to assess the utility of CHI3L1 for predicting outcome of infection. Area under the curve for CHI3L1 is 0.84 (95% CI 0.76-0.92). Parasitaemia (often used clinically for prognosis) is shown for comparison with area under the curve 0.66 (95% CI 0.56-0.75).

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Malaria Journal

ISSN: 1475-2875

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